Hereditary Spastic Paraplegia
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What is Hereditary Spastic Paraplegia?Is there any treatment?What is the prognosis?What research is being done?OrganizationsWhat is Hereditary Spastic Paraplegia?
Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders
that are characterized by progressive weakness and stiffness of the legs. Though the primary feature of HSP is severe, progressive,
lower extremity spasticity, in more complicated forms it can be accompanied by other neurological symptoms. These include
optic neuropathy, retinopathy (diseases of the retina), dementia, ataxia (lack of muscle control), icthyosis (a skin disorder
resulting in dry, rough, scaly skin), mental retardation, peripheral neuropathy, and deafness. Diagnosis is primarily by neurological
examination and testing to exclude other disorders. Specialized genetic testing and diagnosis are available at some medical
centers.
Is there any treatment?
There are no specific treatments to prevent, slow, or reverse HSP. Symptomatic treatments used for other forms of chronic
paraplegia are sometimes helpful. Regular physical therapy is important for improving muscle strength and preserving range
of motion.
What is the prognosis?
The prognosis for individuals with HSP varies. Some cases are seriously disabling while others are less disabling and are
compatible with a productive and full life. The majority of individuals with HSP have a normal life expectancy.
What research is being done?
The NINDS supports research on genetic disorders such as HSP. Genes that are responsible for several forms of HSP have already
been identified, and many more will likely be identified in the future. Understanding how these genes cause HSP will lead
to ways to prevent, treat, and cure HSP .
Select this link
to view a list of studies currently seeking patients.
Organizations
Prepared by:
Office of Communications and Public Liaison
National Institute of Neurological Disorders and Stroke
National Institutes of Health
Bethesda, MD 20892
NINDS health-related material is provided for information purposes only and does not necessarily represent endorsement by
or an official position of the National Institute of Neurological Disorders and Stroke or any other Federal agency. Advice
on the treatment or care of an individual patient should be obtained through consultation with a physician who has examined
that patient or is familiar with that patient's medical history.
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Last updated June 19, 2007
